Molecular underpinning of intracellular pH regulation on TMEM16F
نویسندگان
چکیده
منابع مشابه
Regulation of intracellular pH.
The approach that most animal cells employ to regulate intracellular pH (pH(i)) is not too different conceptually from the way a sophisticated system might regulate the temperature of a house. Just as the heat capacity (C) of a house minimizes sudden temperature (T) shifts caused by acute cold and heat loads, the buffering power (beta) of a cell minimizes sudden pH(i) shifts caused by acute aci...
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Despite earlier notions that intracellular pH (pHi) was invariant with time, recent studies have documented pHi changes of from 0.1 to 1.6 U during metabolic and developmental transitions in a variety of cells. Here we review the evidence for pHi-mediated regulation of gamete activation, cellular dormancy, the cell cycle, and stimulus-response coupling. Intracellular Ca2+ level changes also acc...
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The intracellular pH (pHi) of isolated human peripheral blood neutrophils was measured from the fluorescence of 6-carboxyfluorescein (6-CF) and from the equilibrium distribution of [14C]5,5-dimethyloxazolidine -2,4-dione (DMO). At an extracellular pH (pHo) of 7.40 in nominally CO2-free medium, the steady state pHi using either indicator was approximately 7.25. When pHo was suddenly raised from ...
متن کاملRegulation of intracellular pH in eukaryotic cells.
The fact that cytoplasmic pH is strictly regulated has only been appreciated during the last 10 years. Eukaryotic cells clamp cytoplasmic pH at 7.0-7.4 by ion transport mechanisms and a high buffering capacity of the cytosol. The values of internal pH observed (pH 7.0-7.4) are higher than expected if the protons had been passively distributed across the cell membrane according to electrochemica...
متن کاملSubcellular and molecular aspects of intracellular pH.
there is not enough information at present to eration of glycogen from lactate in the liver, at work distinguish between that possibility and the alterrates where arterial blood lactate is increased. nate one of a single process which reaches a rate Waddell and Brewer concluded this portion of limiting value at high work rates? the session by presenting two papers which showed Robin asked if al...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2020
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.202012704